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TMS Therapy: A Comprehensive Exploration of its Use in Treating Chronic Depression

Transcranial magnetic stimulation (TMS) – A new hope for treating depression when other treatments have failed or were only partially effective, it is FDA-cleared, non-invasive, and covered by most insurances.

What is TMS therapy? How does it work?

Even though it was mentioned in the 19th century by, In the modern era, it was introduced in 1985, transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation therapy without surgery or nesthesia that helps treat psychiatric disorders like major depression.

We localize areas in the brain(Mapping) and then use high-power magnets that generate magnetic fields to stimulate targeted areas of the brain to alleviate depression. it is also being researched for other brain conditions that show some potentially beneficial results. it is currently FDA-cleared for depression, OCD, and smoking cessation.

When should you try TMS therapy?

According to the National Center for Biotechnology Information, 30-40% of patients experiencing depression don’t respond to traditional treatments like medication and talk therapy. If you have been diagnosed with
depression, and your symptoms have not improved through these traditional methods, you may be a good candidate for this non-invasive brain stimulation therapy with minimum risks and side effects.

What should you do before receiving TMS treatment?

  1. Consult an experienced physician to evaluate and rule out other Medical conditions that may be contributing to the symptoms.
  2. Psychiatric TMS consultation with an experienced physician.
  3. During the initial evaluation, the psychiatric physician will evaluate:

    • If you are pregnant or planning to get pregnant.
    • Have any medical implants around the brain?
    • Have been diagnosed with any other mental health conditions.
    • Have a brain tumor, stroke, or brain injury.
    • List of medications you have been prescribed past and present.
    • History of severe headaches or migraines, seizures, as well as any substance abuse or addiction, including alcohol.

TMS therapy for depression – How does it work?

After the consultation and if it’s been decided that you are a good candidate, treatment begins:

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Step 1: You will sit in a reclining chair with a footrest. The clinician and technician will keep a pillow around your head to make you feel comfortable.

Step 2: You will wear a cotton cap with a mark on the treatment area that is assessed during the Brain Mapping.

Step 3: A certified clinician/technician will secure the electromagnetic coil against your scalp.

Step 4: The electromagnetic coil will stimulate specific nerve cells in your brain, which control mood and depression.

Step 5: The magnetic pulses activate parts of the brain that have decreased activity due to depression and rejuvenate connectivity among the neurons.

Step 6: The stimulation helps to reduce your depression symptoms and can result in”Remission”( full recovery from the episode) or a “Response”( at least 50% Improvement).

An experienced Board Certified Psychiatrist supervises all of the steps with vast familiarity with TMS.

Do you need someone to go with you to the appointment?

You can visit the mental health clinic and go back home alone. However, we welcome guests if you choose to.

TMS therapy is non-invasive. We don’t use anesthetics or sedation.

What are the four different types of TMS therapy?

Traditional TMS therapy: This is the primary form of TMS therapy given to patients with Major Depressive Disorder. Traditional TMS therapy uses low-intensity magnetic pulses to stimulate brain nerve cells that control mood.

Deep transcranial magnetic stimulation (dTMS): dTMS involves a non-invasive brain stimulation technique. The magnetic stimulation is delivered to the deep brain areas.

In deep TMS therapy, physicians use different H-coils to stimulate up to 4cm beneath the skull.

Repetitive transcranial magnetic stimulation (rTMS): During an rTMS treatment session, the patient receives a series of brief, repeated, and highly focused magnetic pulses called a pulsed magnetic field. These pulses stimulate brain cells in treating MDD.

The treatment session lasts for about 19 to 37 minutes while patients recline in a comfortable chair. The patient remains awake and aware during all TMS treatment sessions. There is no medication necessary during
treatment, and the patient generally experiences minimal side effects. The patient could relax, listen to music, or see videotapes during the treatment.

The treatment usually consists of five sessions per week for 5-6 weeks. Most patients will experience a lift in symptoms around the tenth session after two weeks of rTMS.After that, we may taper down to 2 times/week for another 3 weeks.The total average treatment is 36 sessions.

Intermittent Theta Burst Stimulation (iTBS): iTBS is an express 3-minute and 9 seconds session. iTBS uses a unique, higher frequency magnetic pulse that enables faster delivery of magnetic stimulation therapy.

iTBS, the accelerated form of TMS, consists of:

  1. Routine protocol: five sessions per week for six weeks.
  2. SAINT protocol: 10 sessions of 10 minutes per day with 50-minute intersession intervals for 5 days
  3. Intense modified protocol:

(Variable protocols can be developed on an individually tailored basis.)One example is:

  • Week 1: 3 treatment days, 3 sessions per day (9 total).
  • Week 2: 2 treatment days, 3 sessions per day (6 total).
  • Weeks 3 and 4: 1 treatment day, 3 sessions per day (6 total) for 4 weeks. 15-minute intervals between sessions.

Can you use TMS therapy for other mental health disorders?

TMS therapy is not only an effective treatment for depression, but it can also treat a variety of other mental health disorders.

Generalized anxiety disorder: TMS therapy can treat generalized anxiety when medication and psychotherapy don’t achieve positive results. It helps to reduce anxiety symptoms by controlling nerve cell activity in the prefrontal cortex.

Obsessive-Compulsive Disorder (OCD): According to the National Center for Biotechnology Information, individuals with OCD often have hyperactivity between the striatum and prefrontal cortex. TMS
treatments can reduce the hyperactivity and OCD symptoms. This is already FDA-cleared.

Schizophrenia: Schizophrenic patients often have auditory hallucinations. Magnetic impulses are delivered to the overactive temporoparietal cortex, which is involved in language. This may help to
reduce auditory hallucinations.( this is considered experimental and not FDA-cleared yet)

Alzheimer’s disease: According to the National Center for Biotechnology Information, TMS therapy may help to reduce Alzheimer’s symptoms by changing the neural connections between memory and learning. (not FDA cleared but may be helpful based on experience in the very early stages of what’s called MCI)

Post-traumatic stress disorder (PTSD): TMS therapy is quite effective for PTSD. It helps to stimulate the prefrontal cortex and reduce fear and panic. ( it is not FDA-cleared yet)

Stroke rehabilitation: The magnetic impulses on the motor cortex help to promote motor recovery after a stroke. The motor cortex regulates voluntary movement. ( experimental, not FDA approved, but may be beneficial)

Nicotine addiction: TMS therapy stimulates the prefrontal cortex. It also helps to trigger the release of dopamine, lowering nicotine cravings. ( this is FDA-approved with a specific magnet and protocol)

Severe pain: TMS therapy stimulates the motor cortex and neurotransmitters involved in pain. This can give you relief from chronic pain. ( not FDA approved different Protocols are used with some success)

Multiple sclerosis: TMS treatment, along with physical therapy, can help to reduce spasticity. The stimulation helps to reduce muscle tightness and promotes body movement. ( not FDA approved but
anecdotally noticed to be very beneficial)

Side effects of other Depression treatments compared to TMS therapy?

Side effects of Medication and Electroconvulsive therapy are much more common and disturbing, including cognitive side effects, weight gain, sexual adverse events, Sleep disturbances, gastrointestinal side effects, etc…

By comparison, the side effects of TMS therapy are minimal and mild.

Can TMS therapy damage your brain?

Clinical studies on long-term exposure to TMS therapy have not found any evidence of brain tumors in patients as a result of the therapy. It also does not cause memory loss or a reduction in concentration, or any other CNS side effects.

What are the eligibility criteria for TMS therapy?

Failure (or side effects) of antidepressants: FDA recommends TMS for patients who did not experience positive results or had no response to 1-2 adequate antidepressant trials.

Most insurances such as Aetna, Cigna, Medicare, and Tricare require a trial of two antidepressants and psychotherapy (ex: 12 sessions of Cognitive Behavioral Therapy (CBT) for MDD).

Age: You should be at least 18 years old for insurance coverage.

Experience shows success with teenagers with TRD(off-label)

TMS therapy, Medication and ECT – A comparative study

What to consider ECT Medication TMS Conclusion

TMS therapy is better than medication and ECT

Do you need to get hospitalized? Yes sometimes No No
Are there any significant side effects? Yes Yes No
Is it non-invasive? No Yes Yes
Is it painful? Not much(done under anesthesia) No No
Is it FDA-approved? Yes Yes Yes
Is it effective? Response – 66 to 79%, Remission – 47 to 75% Response – 49 to 52%, Remission – 28% Response – 68 to 70%, Remission – 45%
Do you need sedation? Yes No No

How much does transcranial magnetic stimulation cost?

The cost of TMS therapy depends on several factors. To get an idea of the overall cost,
is a great place to start.

The FDA approved TMS therapy to treat patients in 2008. Health insurance plans provide coverage for TMS therapy, as well. This will help to ease some of the financial burdens of your treatments.

Does Medicare cover TMS therapy?

Medicare covers TMS treatments only when talk therapy and medication have not helped to reduce your depression and anxiety symptoms.

What is the average TMS success rate?

The average success rate of TMS therapy is between 58% to 67%. The success rate of our psychiatrists is 80 -90 %.

Is TMS therapy safe? Is it suitable for everyone?

TMS therapy is safe. However, you should avoid it if you have stents, metal plates, metallic facial tattoos, and metallic coils in your body due to the strong magnetic fields released during rTMS.

MagVenture Brainsway Neurostar Magstim CloudTMS
rTMS Yes Yes Yes Yes Yes
iTBS Yes Not FDA approved Yes Yes Not FDA approved
OCD D-B80 H7 No No No


Is TMS a hoax?

No. In fact,
have found TMS to be effective against treatment-resistant depression. Harvard Health also states that about 50% to 60% of people with depression experience a clinically meaningful response to TMS.

How long does TMS last?

Does TMS work for anxiety disorders?

Can TMS make depression worse?

Does TMS hurt?

Does TMS make you tired?

Edited by, On Jun 16, 2023